Viral Vectors
By removing the ability to replicate, Adeno associated viruses can be used as a safe tool to deliver small sequences of genetic information into neurons and other brain cells. The targeting of those neurons is highly specific and allows us to express the genes only in cells of interest. Those could be Oxytocin producing neurons or Oxytocin receptor expressing neurons in distinct regions of the brain.
We specialised in the developement and production of a variety of AAVs which not only allow specific cell targeting but also endogenous stimulation or inhibition. A full list of our currently available viruses can be found below:
| NR. | Construct | Map | Date |
| A 48 | OTp_iCreW | Map | 08.11.17 |
| A 51 | A51 pAAV-6P-Vsp-Venus | Map | 12.04.17 |
| A 66 | AAV-CbA-cre-Ires-GFP (96a) | Map | 21.10.15 |
| A 68 | AAV-CBAcre | Map | 16.04.20 |
| A 69 | Syn p_tdTomato | Map | 03.02.15 |
| A 71 | CBAp_TVA_IRES_tdTomato | Map | 15.11.17 |
| A 75 | VPp(1.9)_tdTomato | 04.11.15 | |
| A 77 | AAV-Oxy dttom(AAV-OTp-tdTomato) | Map | 02.07.14 |
| A 82 | VPp(1.9)_iDTR_IRES_EGFP | 30.07.14 | |
| A 83 | VPp(1.9)_TVA_IRES_tdTomato | 15.02.10 | |
| A 85 | AAV_OTp_Venus (OT-V) | Map | 11.10.17 |
| A 89 | AAV_OTp_ChR2-mcherry | Map | 21.06.17 6.12.18 |
| A 90 | VPp(1.9)_ChR2-mCherry (-WPRE) | Map | 24.05.17 |
| A 92 | AAV_EF1a p-DIO_hCHR2(H13R)-EYFP | Map | 19.10.13 |
| A 96 | AAVCAG-Flex-ChR2mcherry RW JFRC,Sternson | 5.03.14 | |
| A101 | VPp(1.9)_iCre_IRES_EGFP | Map | 08.11.17 19.08.20 |
| A103 | AAV_VPp_Venus | Map | 13.11.13 28.09.16 |
| A107 | VPp(1.9)_RG | Map | 15.02.10 |
| A109 | AAVEF1a p_DIO_TTLC-ko | Map | 05.07.17 |
| A110 | AAV_VPp_TTLC_ko(+Wpre | Map | 03.09.13 |
| A111 | AAV_OTp_TTLC-ko(-Wpre | Map | 02.08.13 |
| A112 | AAV_CamKIIa p_Arch3.0-EYfP | Map | 25.04.13 |
| A113 | AAV_CamKIIa p-hCHR2(134a)-mcherry | Map | 25.04.13 |
| A121 | EF1a p_ DIO_ Synatophysin-GFP | Map | |
| A125 | AAV_OTp_HaloR | Map | |
| A126 | AAV_EF1a p_miRNAoxyR1 | Map | 06.06.13 |
| A127 | AAV_EF1a p_miRNAoxyR2 | Map | 29.05.13 |
| A128 | AAV_EF1a p_miRNAoxyR3 | Map | 06.06.13 |
| A129 | AAV_EF1a p_miRNAoxyR4 | Map | 27.06.13 |
| A130-133 | pAAV_EF1a_miRNAVasR20-23 Mix(Judith8) | Map | 05.03.14 |
| A137 | pAAV_EF1a-DIO_ mcherry WPREpA | Map | 24.03.17 14.04.20 |
| A139 | EF1a-DIO p_GFP | Map | 23.07.13 |
| A140 | AAV_CMVp_Tre_CHR2-YFP | 03.07.13 | |
| A141 | AAV_CMVp_hm4D-mcherry | 02.08.13 | |
| A142 | AAV_OTp_htArch3.0-EYFP | Map | 08.08.13 |
| A143 | AAV_EF1a p_DIO_EYFP_WPR | Map | 10.10.18 20.02.19 |
| A144 | EF1a p _DIO_EYFP_WPRE_ires_CR | Map | 11.07.13 |
| A147 | AAV_tetbi p_YC3.6_icre | 18.10.17 | |
| A148 | AAV_tet07 p_fos_rtTA | Map | 09.07.14 06.03.19 |
| A151 | AAV_OTp_DIO_TTLC-ko | Map | 13.08.13 |
| A152 | AAVOxypAGFP | Map | 19.03.14 |
| A153 | AAV_Otp_Oxygene7.5_Wpre | Map | 12.02.14 |
| A154 | AAV_VPp_CREB3L1 | Map | 13.11.13 |
| A157 | AAV_Otp_Oxygene8.5_WPRE | Map | 12.02.14 |
| A158 | AAV_OTp_DIO_GFP | Map | 14.05.14 |
| A160 | AAV-Syn p_DIO_H2B-RFP | 28.01.14 | |
| A161 | AAV CamKII-DIO EYFP | 22.02.17 | |
| A162 | AAV_EF1a p-DIO_HaloR | 19.12.13 | |
| A163 | cfos p cre ERT2 | Map | 12.02.14 |
| A164 | AAVEFdoublefloxed HR-EYFP | Map | 26.03.14 |
| A165 | AAVOTp_CREB3L1 | Map | 08.11.17 |
| A168 | AAV_Opto_oxy-4 | Map | 29.07.11 |
| A171 | pAAV_EF1a_DIO_hChR2(H134R)-mCherry-WPRE- | Map | 12.03.14 6.03.19 14.04.20 |
| A172 | AAV_syn_DIO_hM3DGqmcherry | Map | 16.04.15 |
| A175 | pAAV-OxyP_hNPY-mcherry-WRE (Judith19) | Map | 12.03.14 |
| A176-179 | AAVEF miRNA VasR mix | Map | 19.03.14 |
| A180 | AAV_OTp_hM3D(Gp)-mcherry | Map | 11.07.18 06.03.19 30.01.19 |
| A181 | AAV_OTp_hM4D(Gi)-mcherry | Map | 22.08.18 |
| A182 | AAV-OTp_NPY-phluorino(mit WRE) | Map | 30.04.14 |
| A183 | AAV-OTp_NPY-phluorino(ohne WRE) | Map | 30.04.14 |
| A184 | AAV_SYNstop hM3D(Gi)-mCherry | Map | 07.05.14 |
| A185 | AAV_SYNstop hM3D(Gq)-mCherry | Map | 07.05.14 |
| A187 | AAVOTp-oxygeneElephant7.5 | Map | 06.08.14 |
| A188 | AAVOTp_DIO CHR2(H134)_mcherry | Map | 20.08.14 |
| A190 | VPpromoter-pKillerred-mem(Evrogen | Map | 13.08.14 |
| A191 | AAVOTp_GCamP6f3 | Map | 10.09.14 |
| A192 | AAV_OTp_GCamP6s | Map | 23.08.17 01.08.18 |
| A193 | AAV-VasP-taCasp3-TEVp | Map | 08.10.14 |
| A194 | AAV_VasP_HR-EYFP wo WER | Map | 21.01.15 |
| A195 | AAVOTp-DIO_ChR2-EYFP | Map | 22.10.14 |
| A196 | AAVOTp-Dio_HR-EYFP | Map | 22.10.14 |
| A197 | AAVOTp-ChR2-EYFP | 05.11.14 | |
| A200 | AAV-EF1a-GFP | Map | 09.02.15 |
| A201 | AAV-Ef1a-mcherry | Map | 09.02.15 |
| A203 | AAV-OTp-C1V1(t/t)-TS-mcherry | Map | 01.04.15 |
| A204 | AAV-EF1a -C1V1(t/t)-TS-mcherry | Map | 01.04.15 |
| A205 | Aav-Gfa-C1V1-TS mcherry( Mit AAV 1/2) | Map | 29.06.16 10.10.16 |
| A206 | AAVCaMKII-hM3D(Gq)-mCherry | 01.07.15 | |
| A207 | pAAVCAMKII_hM4D(Gi)mcherry | Map | 01.07.15 |
| A208 | AAVOTp_DIO_mcherry -wre5 | Map | 22.07.15 |
| A211 | AAV_Otp_mcherry | Map | 29.06.16 |
| A212 | AAV_Otp_DIO_gCam6s | Map | 07.10.15 |
| A213 | AAV_synP_Campari | Map | 28.10.15 |
| A214 | AAV_Otp_Campari | Map | 25.11.15 |
| A215 | AAV_EF1a_DIO_NPY-mcherry | Map | 25.11.15 |
| A216 | pAAVEF1a_DIO_NPY-phluorino | Map | 02.12.15 |
| A218 | pAAVEF-DIO-Campari | Map | 09.12.15 |
| A220 | pAAVVa(1.9)HUsHshRNA 1 | Map | 16.12.15 |
| A221 | pAAVVa(1.9)HUsHshRNA 2 | Map | 16.12.15 |
| A222 | pAAVVa(1.9)HUsHshRNA3 | Map | 03.02.16 |
| A223 | pAAVVa(1.9)HUsHshRNA4 | Map | 03.02.16 |
| A224 | pAAVVa(1.9)HUsHshRNA 5 Kontrolle | Map | 10.02.16 |
| A225 | AAV_EF1a_OTR-ires_GFP | Map | 17.02.16 |
| A226 | AAVVasHspa5 | Map | 10.02.16 |
| A227 | AAV_EF1a_DIO_OTr_ires_GFP.(64 | Map | 13.04.16 |
| A228 | AAV-OTp-HA_Kordes_ires_mCitrine | Map | 17.02.16 |
| A229 | AAV_OTp-DIO-HA_Kordes_ires_mCitrine | Map | 06.04.16 |
| A230 | AAVEF1a-DIO-SynaptophysinEGFP (Deussing) | Map | 11.05.16 24.10.18 |
| A231 | AAVOTp_DIO_RG (67-2 | 06.04.16 | |
| A234 | AAVOTp_DIO_mRFPiresT800 | 27.04.16 | |
| A236 | AAV-C-fos rtTA | Map | 01.06.16 |
| A238 | AAVgfaA-GCamP6s3 | Map | 27.07.16 |
| A239 | pAAVEF1a GCamP6s3 WPr epA | Map | 10.08.16 |
| A244 | AVOTp_RG (76) | Map | 26.10.16 |
| A246 | A246 AAVGFAP-hM4D6i-mcherry (77) | Map | 30.11.16 |
| A247 | AAV_GFAP-DIO GCaMP6 | Map | 30.11.16 |
| A248 | AAVEF1a_DIO_C1V1-mcherry | Map | 07.12.16 |
| A249 | pGFAP-DIO_C1V1mcherry | Map | 07.12.16 |
| A251 | AAV EF1a-DIO_hM3D(Gq)-mcherry | Map | 21.01.17 24.09.18 |
| A252 | AAV EF1a-DIO_hM4D(Gi)-mcherry (84) | Map | 21.01.17 24.10.18 09.04.20 |
| A253 | AAVTHprom_GFP(82 | Map | 24.05.17 |
| A254 | AAVTHprom ChR2-mcherry | Map | 24.05.17 |
| A255 | AAVOTp-DIO-mcherry(-WRE)(87) | Map | 24.05.17 |
| A256 | AAV-Otp-ROBO2 | Map | 24.05.17 |
| A257 | VasP -hM3D(Gp) (89) | Map | 26.07.17 |
| A258 | AAV-VasP-hM4D(Gi) | Map | 16.08.17 |
| A259 | pAAV-EF1a-DIO HA-UPRT_ires-EYFP (91) | Map | 30.08.17 |
| A260 | AAVEF1a-C1V1mcherry | Map | 30.01.18 |
| A261 | AAVOTp-DIO-hM4D(Gi)-mcherry | Map | 14.12.17 |
| A262 | AAV.CamKII-HeleroEYFp(94) | Map | 14.12.17 |
| A263 | AAVOTp-DIO-hM3D(Gq)mcherry(95) | Map | 24.01.18 |
| A264 | AAVVasP-GcamP6s3 | Map | 07.03.18 |
| A265 | AAVOTpsynGFP | Map | 26.10.16 |
| A266 | pAAV-Ef1a-DIO-oG-WPRE-hGH | Map | 20.06.18 |
| A267 | AAV-OTp-ihres-icre | Map | 20.06.18 |
| A268 | AAVOTpT800-ires-tom(98) | Map | 11.07.18 |
| A269 | AAV-CAG-DIO-TCB. | Map | 08.08.18 |
| A270 | AAVGfa-GFP-ihres-icre | Map | 24.09.18 |
| A271 | AAV-Ef1a-DIO-GCamP6s3 | Map | 10.10.18 |
| A272 | AAVOTp-oxytocin-ihres-V | Map | 12.02.19 16.04.20 |
| A273 | AAV-OTp-oG | 20.02.19 06.03.19 | |
| A274 | AAV_EF1a-DIO-H2B-GFP-2A-oG-WPRE-hGH | Map | 09.07.2020 |
| A275 | AAV_OTp_oG_mcherry | Map | 03.06.2020 |
| A276 | AAV_GFAP_OptoGq_EYFP | 15.04.2020 | |
| A277 | AAV_GFAP_OptoGq_mcherry | 09.07.2020 | |
| A278 | OTp_ChrimsonR_mScarlet | 19.08.2020 | |
| A279 | Syn_jRCaMP1a | 22.07.2020 | |
| A280 | OTp-jRCaMP1a | 22.07.2020 | |
| A281 | GFAP_jRCaMP1a | 03.06.2020 | |
| A282 | Ef1a_DIO_taCasp3_TEV | 21.01.2021 | |
| A284 | Syn_OXT1.0-long | 11.08.2021 | |
| A285 | EFS_DIO_OXT1.0-long | 11.08.2021 | |
| A286 | Syn_DIO_GCaMP8m_WRPE | 27.08.2021 | |
| A287 | CAG_DIO_RCaMP1a | ||
| A288 | hSyn-BiPOLES-mCerulean | ||
| A289 | hSyn-Dio-BiPOLES-mCerulean | ||
| Boxes | |||
Zentralinstitut für Seelische Gesundheit (ZI) - https://www.zi-mannheim.de